The 5th Annual Johns Hopkins All Children’s Hospital (JHACH) Research Symposium held in late October featured invited talks, oral abstract presentations, and poster abstracts from clinical, translational, and basic scientists—from seasoned internationally renowned pediatric investigators to trainees.
The symposium is a key component in growing Johns Hopkins All Children’s research mission and facilitating research developments for pediatric health. The event promotes research networking and a vibrant, collaborative academic environment of discovery. It serves as a vehicle for sharing innovative research findings among researchers from multiple disciplines dedicated to improving children’s health.
“The abstracts and posters presented at the symposium underscore the diversity and quality of the research efforts at Johns Hopkins All Children’s. Most impressive was the breadth of involvement of all the clinical centers and the numbers of residents, fellows, physicians and nurses who participated. The JHACH research mission has and will make a difference in how we care for our patients in the future,” says George Dover, M.D., professor and immediate past director of the Department of Pediatrics at the Johns Hopkins University School of Medicine and former pediatrician-in-chief of the Johns Hopkins Hospital and co-director of the Johns Hopkins Children's Center, who currently focuses his efforts in helping to advance the academic mission at JHACH.
Symposium speakers included:
- Jeff Jacobs, M.D., co-director of the Johns Hopkins All Children’s Heart Institute, who presented results from a trainee-led international registry-based analysis on predictors of shunt blockage in children who have undergone congenital heart surgery; Dr. Jacobs served as a mentor for this study, which was selected as the top abstract at the 2016 meeting of the Society for Thoracic Surgeons;
- Prabhu Parimi, M.D., director of the Johns Hopkins All Children’s Maternal, Fetal & Neonatal Institute, described new understanding of the brain-gut-lung axis in newborns and evidence for a harmful role of dysbiosis (an imbalance of bacteria within the gut) in premature infants; and
- Peter Shaw, M.D., deputy director of the Johns Hopkins All Children's Cancer & Blood Disorder Institute, who spotlighted clinical trial participation in adolescent and young adult oncology.
- Antony Rosen, M.D, vice dean for research and professor of medicine at Johns Hopkins University School of Medicine, gave the symposium's keynote address on the vision for precision medicine.
“What is remarkable about this year's Symposium is that it has built upon the success of previous years, demonstrating how far we’ve expanded the research mission at Johns Hopkins All Children’s,” explains Neil Goldenberg, M.D., Ph.D., director of research at JHACH and associate professor of pediatrics in the division of hematology, Johns Hopkins University School of Medicine. “We have seen a higher quality and greater quantity of original research presentations than ever before. And, we have leveraged our growing cadre of premier faculty experts in their fields to provide several in-depth overviews of emerging problems and themes in child health and disease research.”
Goldenberg, who also directs the hospital's pediatric thrombosis (blood clot) and stroke clinic, was recently awarded a NIH U01 grant to lead an international randomized clinical trial designed to define the future optimal care in anticoagulant therapy for blood clots in patients less than 21 years old.
“The innovative studies —whether led by senior scientists or by our pediatric residents—are remarkable examples of the power of team science going on every day at JHACH,” Goldenberg concludes.
Symposium Award Winners
Best Trainee-Led Research: Rajiv R. Iyer, MD (Neurosurgery Fellow) “Staged Resection of Large Supratentorial Brain Tumors in Infants in Young Children with Interval Neoadjuvant Chemotherapy Allows for Maximal Safe Resection”
Basic Science: Myrna L. Ortiz-Ruiz, MS “Immune Checkpoint Targeting to Improve Immunotherapy for Neuroblastoma” (from Moffitt Cancer Center)
Best Clinical & Translational: Adrian L. Turner, PharmD (Amanda Memken, PharmD, accepted on behalf of the team) “Increased Risks of Both Bleeding and Recurrent Thromboembolism with Intravenous Enoxaparin When Compared to Subcutaneous Enoxaparin Twice-Daily for the Treatment of Acute Thromboembolism in Critically-ill Infants and Children”
Quality & Safety Awards
Hospital-wide Project: “Standardizing Total Parenteral Nutrition to Reduce Errors.”
Project team members: Fauzia Shakeel, M.D., Jacquelyn Crews, M.D., Russell Sayles, Pharm.D., Jazmine Mateus, M.P.H., Kathy Renn, A.R.N.P., Denise Remus, PhD, R.N., Jeanne Farrell, M.S., Danilo Escoto, M.D., Stacey Stone, M.D., Melanie Newkirk, M.S., Oscar Winners Mendizabal, M.D., Michelle Smith, M.D., Paola Dees, M.D., Elena Rueda-de-Leon, M.D., Sean Butler M.D.
Unit/Local Project: “Growing the Herd: Improving Immunization Rates in Primary Care.”
Project team members: Rachel Dawkins, M.D., Christine Moore, A.R.N.P., Bob Warfield, R.N., Vicki Dunn, R.N., Melissa Brinn, M.D., Heinz Chavez, M.D., Raquel Hernandez, M.D., Jane Sando, M.D., Kristen Maddox, L.P.N., Edgar Arellano, L.P.N., Sherri Hess, L.P.N., Angela McKeown, M.A., Janelle Carter, M.A., Sade Campbell, Lori Avery, Carol Ventura, Dipti Amin, M.D., and all of the JHACH pediatric residents.