Office of Medical Education

Clinical and Translational Research Opportunities


The JHACH Clinical and Translational Research Organization (CTRO) was established to facilitate clinical and translational research development in pediatrics with reach throughout the region, in Baltimore, and beyond.

The CTRO provides a centralized infrastructure to enhance and support the design, execution, and oversight of both clinical research and translational research, in fulfillment of the research mission at JHACH. This mission is to improve the health of children by providing patients and health care professionals with access to innovative pediatric research opportunities to advance the diagnosis, treatment and prevention of pediatric-onset diseases and their adverse outcomes. To find out more about our core services, click here.

Clinical Research and Trials Experience

Annually JHACH conducts approximately 300 IRB-approved, active studies; over half of these are clinical trials. Nearly all prospective studies are now supported by CTRO personnel.

Multicenter Trial Leadership

JHACH is the Clinical Coordinating Center for the Kids-DOTT trial, a definitive multicenter randomized clinical research trial to establish the duration of anticoagulation for venous thrombosis in children. This also includes Central Investigational Pharmacy and Central Biorepository roles.

Therapeutic Areas and Expertise

JHACH pediatric research studies address the broad range of areas of child health emphasis and expertise at the St. Petersburg and Baltimore campuses of JHM. Some examples include:

Cardiology/cardiovascular surgery—Congenital heart disease, thromboembolism, arrhythmias, pulmonary hypertension, heart failure, transplantation

Neuroscience—Epilepsy, movement disorders, stroke, bladder reinnervation, Chiari malformation, syringomyelia

Neonatal/perinatal medicine— Prematurity, neonatal abstinence syndrome, hypoxic ischemic encephalopathy, bronchopulmonary dysplasia

Hematology/oncology/hematopoietic stem cell transplantation—Oncology network trials, bone marrow transplant network studies, graft-versus-host disease, thromboembolism, bleeding disorders, sickle cell disease

Pulmonology—Asthma, cystic fibrosis network trials

Endocrinology—Diabetes mellitus, growth failure