Johns Hopkins All Children's Hospital

Center for Pediatric Early-Phase Trials

The Center for Pediatric Early-Phase Trials serves as a resource to investigators, including helping to navigate (in partnership with the Center for Pediatric Clinical Research Training, Education and Engagement) investigators through review and approval processes and engaging the expertise of cores and shared resources in order to enhance efficiency and quality of early-phase trial planning and execution.

The Center also serves as the home of faculty expertise for early-phase pediatric clinical trial design and conduct, providing consultation and mentorship and enabling collaboration and knowledge-sharing. The Center fosters collaboration among Johns Hopkins All Children’s clinical and laboratory investigators, and with external collaborators, to perform PK/PD analyses and to plan and execute investigations of biologic correlates as part of phase 1 and 2 clinical trial designs.

Meet Our Team

Jonathan Metts, M.D., Co-Director

Instructor of Oncology, Johns Hopkins University School of Medicine; Member, Johns Hopkins All Children’s Cancer & Blood Disorders Institute

Ernest Amankwah, Ph.D.

Assistant Professor of Oncology, Johns Hopkins University School of Medicine; Epidemiologist, Epidemiology & Biostatistics Unit, Johns Hopkins All Children’s Health Informatics; Member, Johns Hopkins All Children’s Cancer & Blood Disorders Institute

Pat Brown, M.D.

Associate Professor of Oncology, Johns Hopkins University School of Medicine (Baltimore-based)

Michael Cohen-Wolkowiez, M.D., Ph.D., external adviser and collaborating investigator

Professor of Pediatrics, Duke University School of Medicine; Director, Duke Clinical Research Unit and Pharmacometrics Unit, Duke Clinical Research Institute

Heather Cronin, M.Sc.

Manager, Investigational New Drug/Investigational Device Exemptions Support Unit, Johns Hopkins All Children’s Clinical/Translational Research Shared Resources

Jason Fangusaro, M.D., external adviser and collaborating investigator

Associate Professor of Pediatrics, Emory University School of Medicine; Director, Developmental Therapeutics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta

Andrea Farkas, R.N., M.N.

Manager, Clinical Research Unit, Johns Hopkins All Children’s Hospital

Prem Fort, M.D.

Assistant Professor of Pediatrics (Neonatology), Johns Hopkins University School of Medicine; Neonatologist, Johns Hopkins All Children’s Maternal, Fetal & Neonatal Institute

Neil Goldenberg, M.D., Ph.D.

Associate Dean for Research at Johns Hopkins All Children’s Hospital; Professor of Pediatrics and Medicine, Johns Hopkins University School of Medicine; Director of the Johns Hopkins All Children’s Institute for Clinical and Translational Research

Collin Hovinga, PharmD, external adviser and collaborating investigator

Senior Vice President, Clinical and Scientific Development, Institute for Advanced Clinical Trials (I-ACT) for Children; Clinical Associate Professor, University of Texas at Austin; Former Member, FDA Peripheral and Central Nervous System Advisory Committee

Dawn Napolitano, PharmD

Manager, Johns Hopkins All Children’s Investigational Drug Services Unit 

Benjamin Oshrine, M.D.

Assistant Professor of Oncology, Johns Hopkins University School of Medicine, Chief of Bone/Marrow Transplantation and Cellular Therapies, Johns Hopkins All Children’s Cancer & Blood Disorders Institute

Damon Reed, M.D.

Assistant Professor, University of South Florida Morsani College of Medicine; Associate Member, Sarcoma Department, Moffitt Cancer Center

Daniel Schaufelberger, Ph.D., external adviser and collaborating investigator

Former Scientific Director, Pharmaceutical Development & Manufacturing Sciences, Pediatric Center of Excellence, Janssen R&D