Molecular Determinants Core

We provide metabolomics services for researchers in a wide range of medical specialties and disciplines.

The Molecular Determinants Core at Johns Hopkins All Children’s Hospital provides state-of-the-art services for researchers in metabolomics, lipidomics, peptidomics and proteomics. We have developed a process to isolate proteins, peptides, metabolites and lipids from the same sample, in a manner compatible with both targeted and profiling mass spectrometry technologies.

We support a wide range of clinical studies from sample collection, processing and storage, to complex clinical data analysis, offering competitive pricing.

The Molecular Determinants Core is a collaborative effort between Johns Hopkins All Children’s in St. Petersburg, Florida, and the Johns Hopkins University School of Medicine in Baltimore with support from the All Children’s Research Institute. We strive to act as a focal point and resource for the free exchange of knowledge, method development, sharing of experience, strengthening of intra- and inter-institutional collaborations in “omics” technologies, and fostering interactions with industry and leaders in the field of integrative biology.

Services we offer include:

• Expert consulting for grant applications
• Practical assistance for experimental design and sample collection
• Sample preparation customized to your samples and needs
• Variety of metabolomics assays, including customized assays
• Expert data analysis

Learn more about our services.

Selected Research Publications

• Cyclohexanone Exposure in Children on Extracorporeal Membrane Oxygenation Support
• Neonatal encephalopathy plasma metabolites are associated with neurodevelopmental outcomes
• Association of Neurodevelopmental Outcomes With Environmental Exposure to Cyclohexanone During Neonatal Congenital Cardiac Operations: A Secondary Analysis of a Randomized Clinical Trial
• Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research
• Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons
• Perioperative Metabolites Are Associated With Adverse Neonatal Congenital Heart Disease Surgical Outcomes
• PHARMACOLOGICAL MODULATION OF NMN AND NAD (+) METABOLISM PROTECTS AGAINST WALLERIAN DEGENERATION IN MAMMALIAN AXONS
• Neonatal encephalopathy plasma metabolites are associated with neurodevelopmental outcomes
• Metabolic profiling of pulmonary vascular phenotypes in systemic sclerosis
• Circulating Amino Acid Profiles in Pulmonary Arterial Hypertension at Rest and with Peak Exercise
• Evolving Metabolism Predicts Development of Pulmonary Arterial Hypertension in Systemic Sclerosis

Related Articles

Imagining a New Future for Biomedical Blood Sampling and Preservation

Johns Hopkins All Children’s researchers advance the use of dried blood spot sampling, to enable greater access and accuracy.

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Why He Seeks to Discover

David Graham, Ph.D., director of the Molecular Determinants Core at Johns Hopkins All Children’s Hospital, found a calling to science at a young age.

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