Education

• B.S., Biotechnology, China Agricultural University, China, 2007
• Ph.D., Biotechnology, Peking University, China, 2012
• Postdoctoral Fellow, Biological Sciences, University of California San Diego, California, 2014
• Postdoctoral Fellow, Molecular Medicine and Immunology, National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH), Maryland, 2021

Overview

Dr. Xiong is an assistant professor of medicine in the Division of Endocrinology, Diabetes and Metabolism at the Johns Hopkins University School of Medicine. His research focuses on the cytokine and metabolic regulation of cell fate and function, ranging from basic molecular mechanisms to human disease. His research aims to understand the mechanisms of how cytokine signaling and vascular-immune crosstalk contribute to physiology and pathophysiology, and to facilitate the development of new therapies for metabolic, cardiovascular and inflammatory diseases as well as cancer. Dr. Xiong’s laboratory uses systems cell biology and immunology approaches to identify novel molecular and cellular targets that can be harnessed for cell therapy, immunotherapy and drug discovery. 

Honors and Awards

• NHLBI/NIH Career Transition Award K22, 2019-2024
• NIH “Earl Stadtman Investigators” Program Finalist, 2019-2021
• NIH Summer Research Mentor Award, 2019
• Elected Member, NIH Immunology Interest Group Steering Committee, 2018-2019
• Young Investigator Award, NIH Asian and Pacific Islander American Organization, 2018
• Best Poster Award, NIH-Chinese Students & Scholars Association Symposium, 2018
• Gu-Wu Award for Research Excellence, Peking University, 2012
• Sempio Award for Research Excellence, Peking University, 2011
• May 4th Award for Research Excellence, Peking University, 2010
• Outstanding Graduate Award, Peking University, 2008-2010

Research Interests

Dr. Xiong's research interests include:

• Metabolic and cytokine regulation of the fate and function of cells (e.g., endothelial cell, T cell and epithelial cell)
• Protein-protein interactions in cell signaling and metabolism
• Cytokine-mediated regulation of organ homeostasis and metabolism
• Vascular and immune lineages for cell therapy and drug discovery
• Molecular and cellular interactions in vascular-immune crosstalk in health and disease

Select Publications

• Xiong J, Kawagishi H, Yan Y, Liu J, Wells QS, Edmunds LR, Fergusson MM, Yu ZX, Rovira, II, Brittain EL, Wolfgang MJ, Jurczk MJ, Fessel JP, Finkel T. A Metabolic Basis for Endothelial-to-Mesenchymal Transition. Molecular Cell. 69(4):689–98 e7 (2018). (Editorially highlighted in Nature Reviews Molecular Cell Biology, Trends in Molecular Medicine and Trends in Endocrinology and Metabolism).
• Xiong J. A ‘Nobel’ look at metabolism. Trends in Endocrinology and Metabolism 29, 809–813 (2018).
• Xiong J. Fatty acid oxidation in cell fate determination. Trends in Biochemical Sciences 43, 854–857 (2018).
• Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP and Xu Y. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. Journal of Cell Biology 208(5): 513–520 (2015). (Editorially highlighted in Nature Reviews Molecular Cell Biology and Journal of Cell Biology).
• Xiong J, Du Q and Liang Z. Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein. Oncogene (Nature press) 29(35): 4980–4988 (2010). 

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