Director, Center for RNA Biology, and Associate Professor, Department of Oncology, Johns Hopkins University School of Medicine
Two post-doctoral research fellowship positions in basic science in the field of oncology & non-coding RNA research are available in the laboratory of Dr. Perera in the Johns Hopkins All Children’s Institute for Fundamental Biomedical Research.
Find information and requirements for postdoctoral fellow positions:
For more information or to apply, please contact Dr. Perera at firstname.lastname@example.org with a CV including references and a cover letter/personal statement.
- M.S., Cytogenetics, Peoples Friendship University Moscow, 1984
- Ph.D., Molecular Genetics, Moscow University, and DNA Repair and Recombination, University of Gent, Belgium, Adviser: Professor Marc Van Montagu, Ph.D., 1987
- Post-doctoral fellowship, Gene Targeting and DNA Recombination, Massachusetts Institute of Technology, Adviser: Professor Ethan R. Signer, Ph.D., 1994
Dr. Perera is director of the Center for RNA Biology at Johns Hopkins All Children's Hospital, a senior scientist in the Cancer & Blood Disorders Institute and an associate professor of oncology in the Johns Hopkins University School of Medicine. He also has a secondary affiliation with the Johns Hopkins All Children’s Institute for Fundamental Biomedical Research. He uses biology, analytic genomics and bioinformatics to seek patterns that can lead to treatments for aggressive cancers. Dr. Perera’s research focuses on genes and identifying those susceptible to changes that lead to disease. He seeks to identify these changes early in life, which would allow early intervention through surgery or therapies that could prevent or alter the course of the disease.
Dr. Perera worked for several biotech and pharmaceutical companies before joining the faculty at Mercer University’s School of Medicine as an associate professor and director of genomics and research and development at Anderson Cancer Institute at Memorial Health Medical Center. He then worked for the Sanford Burnham Prebys Medical Research Institute before joining Johns Hopkins All Children’s Hospital in 2018. He is also an adjunct faculty in the NCI-designated Cancer Center at Sanford Burnham Prebys Medical Research Institute in La Jolla, California.
Honors and Awards
- Honorary Professor, Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, 1999
- European Economic Community Biotechnology and Genetic engineering scholarship for post graduate studies, 1987
Read more about Dr. Perera's work:
Ranjan Perera, Ph.D., was the senior author on a study that may lead to more effective therapies for medulloblastoma, a common form of pediatric brain cancer.
Childhood cancer medulloblastoma and adult skin cancer metastatic melanoma are difficult cancers to detect early, and once caught late, they are nearly always impossible to cure, causing mortality despite surgery and conventional therapies. Understanding the biology of these aggressive cancers is critical in finding effective treatments.
Dr. Perera's recent research on tumor plasticity has provided a novel direction in the biology of these cancers, and they have found that abnormal patterns of regulation of certain long non-coding RNAs (lncRNAs) and microRNAs genes determine the cancer aggressiveness. These findings support an unorthodox approach in investigating such cancers in that tumor heterogeneity rather than mutational processes might be the important underlying molecular mechanism behind aggressive cancers. Therefore, novel therapeutic strategies might be in order, but much more remains to be understood in this direction. Specifically, the genome-wide systems biology approaches become important when aggressive medulloblastoma and melanoma initiate.
Dr. Perera's lab has embarked upon a systems biology initiative to investigate the role of non-coding RNA expression in these cancers and propose extending this initiative from the laboratory to patients' bedside.
- Sahoo A, Sahoo SK, Joshi P, Lee B and Perera RJ. MicroRNA-211 loss promotes metabolic vulnerability and BRAF inhibitor sensitivity in melanoma. Journal of Investigative Dermatology. 2018; doi: 10.1016/j.jid.2018.06.189.
- Lee B, Sahoo A, Marchica J, Holzhauser E, Chen X, Li JL, Seki T, Govindarajan SS, Markey FB, Batish M, Lokhande SJ, Zhang S, Ray A, Perera RJ. The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules. Science Advances. 2017; 3(5):e1602505. doi: 10.1126/sciadv.1602505.; PMCID: PMC5415337.
- Mazar J, Qi F, Lee B, Marchica J, Govindarajan S, Shelley J, Li JL, Ray A, and Perera RJ. MIR211 functions as a metabolic switch in human melanoma cells. Molecular and Cellular Biology, 2016; 36(7):1090-108. PMCID: PMC4800793
- Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS, Perera RJ. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res. 2011 Jun 1; 71(11):3852-62. PubMed PMID: 21558391.