Cancer and Blood Disorder Institute

Pediatric Blood & Marrow Transplant (BMT) Program

For blood and bone marrow transplants, you can trust Florida’s largest program at the Johns Hopkins All Children’s Cancer & Blood Disorders Institute.

If your child needs a blood or bone marrow transplant, you want the best doctors, technology and treatment options. You want to be sure you’re in the right place for leading-edge therapies to treat the most complex diagnosis. Most of all, you want to be able to trust in the quality and expertise of your team, so you can focus on supporting and caring for your family. 

About Our Transplant Program

We are Florida’s largest pediatric blood and bone marrow transplantation program with excellent outcomes for children who need bone marrow (stem cell) transplants to treat leukemia, lymphoma, immunodeficiency syndromes and other forms of cancer and blood diseases.

Our program was one of the first pediatric centers in the United States to offer “reduced intensity” transplants in an effort to minimize the toxic effects of radiation and chemotherapy. Now, our program provides the full range of blood and marrow transplant services, including bone marrow transplants, peripheral blood stem cell transplants and cord blood transplants.

We perform about 50 hematopoietic stem cell transplants each year. Finding a perfect match for every child is not always possible. Johns Hopkins Medicine developed a new treatment for children unable to receive a typical 100 percent match transplant. Johns Hopkins All Children’s has adopted the haploidentical bone marrow transplant protocol, which allows for a 50 percent match. Children who were once without options can now survive.

We also give our patients access to national and international protocols through our membership in the National Marrow Donor Program, the Pediatric Blood and Marrow Transplant Consortium, the Children’s Oncology Group and the Center for International Blood and Marrow Transplant Research.

Positive Outcomes

The success of a bone or blood marrow transplant (BMT) depends on many things, including the disease type and the relationship of the donor to the patient. Survival rates are measured at 100 days and one year. At Johns Hopkins All Children’s Hospital, our average BMT success rate for years 2014-2016 is 83 percent; in cases of autologous donors (when the cells come from the patient) the survival rate for the same period climbs to 95 percent.

Watch and be inspired by Owen's story:


Owen was an infant when he was diagnosed with a genetic immune system disorder in which certain white blood cells don’t function properly and his family was told he would need a bone marrow transplant. Two months later, a match was found and the Johns Hopkins All Children’s Blood & Marrow Transplant Team successfully performed the procedure. Three years later, Owen and the donor meet for the first time and Owen’s parents share what the life-saving gift has meant for their family.  

As we continue to pursue new methodologies and emerging therapies, we see consistent improvement over time, providing hope and motivating our efforts to provide lifesaving medicine to all. The chart below represents survival rates for the past three years, broken down by donor type. 


1 year
1 year


All transplants 79% 88% 94% 95%
Autologous (patient donor) 92% 100% 100% 100%
Allogenic (family member or
unrelated volunteer donor)
73% 86% 87% 91%

You can view national averages by disease type at the U.S. Department of Health and Human Services.

Clinical Trials

Patients who receive a blood or bone marrow transplant at Johns Hopkins All Children’s may be asked to participate in a clinical trial. A clinical trial is a research study that is designed to help determine the best treatment for a patient with a given disease. These trials help us further our understanding of treatments and diseases, helping us improve care for children with cancer and blood disorders.

Only you as the patient or the child’s parent can decide if participating in a clinical trial is right for you. Participating in a clinical trial is optional, but may benefit children with similar conditions. If you choose to participate, the doctor and the consent document will provide detailed information on the treatment and its potential risks and benefits.

Learn more about our clinical trials.

Affiliation with H. Lee Moffitt Cancer Center

Johns Hopkins All Children’s is the only pediatric affiliate of the H. Lee Moffitt Cancer Center. This formal collaboration enables us develop new and innovative therapies for our patients, including leading-edge stem cell transplants. The team works collaboratively with colleagues at Moffitt Cancer Center, sharing their accreditation with the Foundation for Accreditation of Cellular Therapies (FACT).

Physicians and researchers at Johns Hopkins All Children’s and the Moffitt Cancer Center are working together on trials of new medications and therapies. This research takes new knowledge about the molecular biology and biochemistry of cancer cells, and their response to potential therapies, from the lab bench to the bedside as soon as possible. 

Our Facilities

Our Pediatric Blood and Marrow Transplant Unit is a 28-bed unit that is integrated into the Pediatric Hematology-Oncology Unit (Seven South) at Johns Hopkins All Children’s Hospital.

Our outpatient clinic is located in the Outpatient Care Center directly across the street from our hospital and includes a separate registration area for patients with weakened immune systems. Blood work can be done right in the outpatient clinic, and diagnostic imaging services are available across the street in the hospital.

Program History

Our program was founded in 1985 by Robert Good, M.D., Ph.D., a pioneer in the fields of transplantation and immunology. Dr. Good performed the first successful bone marrow transplant that didn’t involve identical twins in 1967 at the University of Minnesota.

Since that first procedure, more than 100,000 blood and bone marrow transplants have been performed worldwide, and promising new methods of stem cell transplantation are being developed.

Questions? Give us a call

We know that you want the best possible care for your child. Our team is happy to assist you with your questions.

Make an appointment online

 We're ready to work with you to explain your options and discuss the best treatment plan for your child.

Prepare for your stay by reading our Inpatient Family Guide

 It’s a little easier when you know what to expect and understand what’s going on around you. We hope this guide will be a handy source of information about how our Hospital works. If you have questions or need assistance, don't be afraid to ask. We are here to help.