Pediatric Blood & Marrow Transplant (BMT)

Conditions We Treat

The Blood and Marrow Transplant Program at Johns Hopkins All Children’s Hospital treats a variety of cancer and blood disorders in children, adolescents and young adults.

The Johns Hopkins All Children's Blood and Marrow Transplant Program treats a variety of cancers, disorders of the blood and immune system and a wide range of disorders and syndromes. We also treat patients who are born with congenital immunodeficiency syndromes or metabolic disease.

We perform about 50 hematopoietic stem cell transplants each year. Finding a perfect match for every child is not always possible. Our team offers the haploidentical bone marrow transplant protocol, which allows for a 50 percent match.

Types of Blood and Marrow Transplants

Advances in transplantation and the growth of donor registries have provided greater options in the source of stem cells used in transplantation. 

There are three kinds of transplants: 

  • Autologous Transplant. The patient’s own stem cells are harvested through bone marrow or by a relatively simple procedure called leukapheresis.
  • Allogeneic Transplant. The patient receives stem cells from the bone marrow or circulating blood cells from a compatible donor, determined by human leukocyte antigen (HLA) testing. A matched sibling donor is the ideal donor for an allogeneic transplant. Fortunately, most children who do not have an HLA matched donor are able to locate an unrelated donor through the National Donor Marrow Program.
  • Umbilical Cord Blood. Umbilical cord blood from an umbilical cord blood registry or from the birth of a sibling is the third possible source of stem cells for an allogeneic transplant. Cord blood is the blood that is left over in the placenta and umbilical cord that can be stored for later use in a stem cell transplant. The cord blood is kept frozen until needed and is administered to a patient in the same manner as a blood transfusion.  

Diseases and Disorders Treated with Blood and Marrow Transplants

Several diseases and disorders can be treated by blood and marrow stem transplants, including:

Malignant Disorders:

  • Bone tumors 
  • Brain tumors 
  • Leukemias 
  • Lymphomas 
  • Soft tissue tumors

Hematologic Disorders and Bone Marrow Failure Syndromes:

  • Diamond-Blackfan anemia 
  • Fanconi anemia 
  • Severe aplastic anemia 
  • Sickle cell disease 
  • Sideroblastic anemia 
  • Thalassemia

Immunodeficiency Syndromes:

  • Cartilage hair hypoplasia 
  • Chronic granulomatous disease 
  • Leukocyte adhesion defects 
  • Severe combined immunodeficiency (SCID) 
  • Wiskott-Aldrich Syndrome

Inborn Errors of Metabolism:

  • Adrenoleukodystrophy 
  • Hunter Syndrome 
  • Hurler Syndrome 
  • Krabbe disease 
  • Maroteaux-Lamy syndrome 
  • Osteopetrosis 

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