Biorepository

The Johns Hopkins All Children’s Pediatric Biorepository was established in 2013 to assist pediatric researchers and doctors world-wide in: processing, cryopreserving and storing blood, tissue and other biospecimens used for archival and hypothesis-driven clinical research, promoting sample networks and enhancing research collaborations in child health and providing education and training in biorepository science with a special emphasis in pediatrics.

Clinical and Translational Research Organization (CTRO)

The Johns Hopkins All Children’s Clinical and Translational Research Organization (CTRO) was established to facilitate clinical and translational research development in pediatrics with reach throughout the region, in Baltimore, and beyond.

The CTRO provides a centralized infrastructure to enhance and support the design, execution, and oversight of clinical and translational research, in fulfillment of the research mission at Johns Hopkins All Children’s Hospital. This mission is to improve the health of children by providing patients and health care professionals with access to innovative research opportunities to advance the diagnosis, treatment and prevention of pediatric­ onset diseases and their adverse outcomes.

Clinical Research and Trials Experience

Annually, Johns Hopkins All Children’s Hospital conducts approximately 300 IRB-­approved, active studies; over half of these are clinical trials. Nearly all prospective studies are now supported by CTRO personnel.

Institutional Review Board

In addition to the CTRO, Johns Hopkins All Children’s Hospital has an independent pediatric Institutional Review Board that was established in the early 1980s. Effective Fall 2013, this IRB is one of the Johns Hopkins Medicine IRBs.

Multicenter Trial Leadership

Johns Hopkins All Children’s is the Clinical Coordinating Center for the Kids­DOTT trial, a definitive multicenter randomized clinical trial to establish the duration of anticoagulation for venous thrombosis in children. This also includes Central Investigational Pharmacy and Central Biorepository roles.